Saint Louis FC

SLSG Pro LLC (affiliated with St. Louis area youth club St. Louis Scott Gallagher) was awarded the USL Pro franchise on May 1, 2014. That same day, the club announced that they would play their home games at the 5,500 seat World Wide Technology Soccer Park in Fenton, Missouri. Dale Schilly, the youth club director of SLSG, was named head coach.

On June 2, 2014, it was announced that the team's name was Saint Louis Football Club.

Former AC St. Louis player Mike Ambersley was the first player signed to the team on January 13, 2015.

On January 16, 2015, the team announced their affiliation with the Chicago Fire of Major League Soccer.

St. Louis FC played their inaugural game on March 28, 2015, losing to Louisville City 2–0. Their first victory was against the Tulsa Roughnecks on April 2, 2015, winning 2–0. Jeremie Lynch scored the team's first ever goal in the 42nd minute. Their home debut was a 1–1 draw against the Pittsburgh Riverhounds on April 11, 2015, before of a sellout crowd of 5,280. The team's first home win came against the Wilmington Hammerheads on May 9, 2015, with the winning goal by Sam Fink.

On May 16, 2016, Saint Louis FC announced that they had acquired the PDL team Springfield Synergy FC and renamed the team as Saint Louis FC U-23. On August 15, 2016, Saint Louis FC announced that Dale Schilly had been relieved of coaching duties; Tim Leonard was named as interim head coach. On October 12, 2016, Saint Louis FC introduced Preki as the new head coach.

On February 15, 2017, Saint Louis FC and the Chicago Fire did not renew their affiliation for the 2017 season. On November 19, 2017, the club announced that Preki and the club were parting ways by mutual agreement. Anthony Pulis joined the team from Orlando City B to take over the role of head coach the next day.

On August 25, 2020, citing the financial impact of the COVID-19 pandemic during 2020, it was announced that the 2020 season would be the final season of operation for the club.